In order to understand the depth of meaning behind Roman’s 12:21, we have to examine the broader content of Roman’s 12, and the whole book for that matter. But even beyond that, we have to fully grasp the enormity of God’s original creation plunged headlong into sin and despair. God is not willing that any should perish, certainly because it was never God’s intent that sin and disobedience disrupt anything! Though He is all powerful, and capable of utilizing both good and evil for His own glory, that doesn’t change the reality that God initially created all things as, “very good.” It was man who messed things up. It was man who exercised free will in disobedience to a sovereign command. So it is man alone who bears the consequences of sin and iniquity.
The choice made in the garden by the first Adam, caused sin to overcome the world. The book of Romans solidifies the doctrine of the second Adam: He whose character we find exemplified in submitted believers in Roman’s 12. Make no mistake, that’s exactly what is meant by being, “transformed by the renewing of your mind.” The only way to “prove what is that good, and acceptable, and perfect will of God,” is through submission to the control of the very Spirit of Christ. His life through us looks like what’s described in verses 9-21: love without favoritism, hating evil and loving good, brotherly kindness, Christian charity, humbleness of mind, honesty, and loving our enemies to name a few. It’s a reiteration of the teaching of Jesus in the sermon on the mount. It’s the righting of a centuries old wrong. It’s what 1 John describes as Jesus coming that He might, “destroy the works of the devil.” It’s a complete upheaval of the corrupt system of sin and destruction.
To summarize, it’s hope! It’s hope that no matter what evil or persecution may befall the New Testament saint, he or she may triumph over it through Christ. We may triumph because He already did. This isn’t a prosperity teaching, it’s a positional teaching. It’s the concept of always rising above your circumstances, no matter how wretchedly dismal, and walking on the water, with eyes fixed solely on Jesus.